Tag Archives: Biohack

Skin Intelligence

Harnessing and mimicking the skin’s innate, adaptive ability to detect, process, and respond to environmental stimuli and internal signals to maintain its optimal condition.

Science-backed efficacy and safety, sensorial experiences, and natural, skin-identical ingredients are core to NeoGenesis’ technology. Ours is a holistic approach, a systems-therapeutic (Maguire, 2014) approach to skin care, using multifunctional ingredients and products that address both physical appearance and underlying health. Healthy skin is beautiful skin. Dr. Maguire’s revolutionary approach at NeoGenesis is explained in his academic book, “Adult Stem Cell Released Molecules: A Paradigm Shift to Systems Therapeutics” (Nova Science Publishers, 2018); his popular book, Thinking and Eating For Two: The Science of Using Systems 1 and 2 Thinking to Nourish Self and Symbionts (Amazon, 2020), and has garnered interest for years by those in the skin care industry.

Aesthetic treatments have become increasingly destigmatized, as skin experts and influencers sharing these interventions online becomes the norm. These treatments once exclusive to the clinic are now reshaping expectations at home, as demand grows for powerful at-home alternatives delivering visible results – winning on time, budget, ease of use, and of course results. But this shift isn’t just about DIY. It’s about medical-like performance without the costs and negative side-effects. Ingredients mimicking the mechanisms and outcomes of aesthetic procedures are gaining traction — offering smoother, firmer, more volumized skin without a needle in sight. And with nutrition, including caloric restriction, being top of mind, consumers increasingly seek safer, accessible alternatives to GLP-1 medications that mirror or improve their benefits. The result? Skin care that goes beyond hydration, cover-up, or smoothing. NeoGenesis performs like a procedure – delivering clinic-coded results, at home. Those using GLP-1 agonists, for example, will benefit from using NeoGenesis Recovery to remediate the negative consequences of the GLP-1 agonists on the fibroblast and ADSCs in the skin.

Longevity

Longevity has emerged as a central focus in health and beauty, as consumers increasingly seek ways to biohack their bodies for long-term results. This shift from traditional anti-ageing toward a lifespan- and healthspan-driven approach focuses on biological age and prolonging skin life at the cellular and tissue levels, for example, fibroblasts and the extracellular matrix —addressing the root causes of aging. At the same time, the longevity culture strives in lifestyle changes to achieve a healthy mindset and appearance. In line with this trend, the biohacking industry is gaining momentum and can become more accessible due to the “information age.” NeoGenesis is an important part of skin “biohacking,” in the best sense of the word by bridging science, technology, and self-optimization.

Biohacking can include stem cell released molecules (S2RM or S3RM) applied to the skin yielding renewed and optimized mitochondrial function (picture from Kevin Wiener).

Dr. Greg Maguire, Ph.D. – NeoGenesis Cofounder – Top 2% of Scientists

Dr. Greg Maguire of NeoGenesis has a long history in physiology and functional medicine (Maguire, 2013), and his methods for biohacking (Maguire, 2020) are helping to shape a new, performance-driven vision of long-term skin and body care. Whether it’s secretome and exosome technology, naturally sourced skin-identical nutrients as ingredients, or microbiome renormalization using prebiotics, probiotics, and postbiotics (Maguire and Maguire, 2017; 2019), Maguire has introduced these concepts and technologies to skin care.

Dr. Greg Maguire is one of the world’s leading scientists, having an H-index of 41. An H-index of 41 places a researcher in the top 2% of most-cited scientists globally. While precise percentiles fluctuate by field and database, this score is consistently categorized as “outstanding” and is indicative of a scholar at the highest levels of academia.

Web of Science for Dr. Greg Maguire, H-index = 41, placing Dr. Maguire in the top 2% of scientists world-wide.

NeoGenesis is pioneer in science-based dermohacking and continues to harness this disruptive vision by bridging longevity science, nature, and premium skin care experiences to push the boundaries of efficacy, safety, and sustainability. Not only efficacy, but safety is key to optimal biohacking and the NeoGenesis technologies, including our S2RM®-core technology, have extensive, peer-reviewed safety studies backing it (Maguire and Friedman, 2020).

With the technologies developed by Dr. Greg Maguire, the products formulated by Dr. Greg Maguire, Dr. Maguire’s patented S2RM technology produced by the NeoGenesis labs led by Linda Green, who has 30 years’ experience as a biotechnologist, lab-director at the University of Florida, and all of our products made in the NeoGenesis laboratories under the direction of Kevin Wiener, a science-grad from the University of California, Santa Cruz. NeoGenesis uses Just-In-Time manufacturing of our ingredients and products to bring the market the freshest, most innovative, and most powerful, efficacious products available.

Whether it’s skin-identical molecules to those produced in the skin by multiple skin stem cell types (S2RM and S3RM technology), the lipids produced in the skin (Triple Lipid Technology), or the dietary botanical-derived ingredients that are brought to the skin through the blood supply (Vibrant C Serum and Skin Restore Serum Vitamin A), NeoGenesis provides the full spectrum of ingredients needed to return the skin to a healthy state and optimize skin longevity.

References

Maguire G. (2013) Stem cell therapy without the cells. Commun Integr Biol. 6(6):e26631.

Maguire G. (2014) Systems biology approach to developing “systems therapeutics”. ACS Med Chem Lett. 2014 Mar 6;5(5):453-5

Maguire G (2018) Adult Stem Cell Released Molecules: A Paradigm Shift to Systems Therapeutics” (Nova Science Publishers, 2018).

Maguire G (2020) Thinking and Eating For Two: The Science of Using Systems 1 and 2 Thinking to Nourish Self and Symbionts. Amazon Press.

Maguire G, Friedman P. (2020) The safety of a therapeutic product composed of a combination of stem cell released molecules from adipose mesenchymal stem cells and fibroblasts. Future Sci OA. 6(7):FSO592.

Maguire M, Maguire G. (2017) The role of microbiota, and probiotics and prebiotics in skin health. Arch Dermatol Res. 309(6):411-421.

Maguire M, Maguire G. (2019) Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics. Rev Neurosci. 30(2):179-201.

Turning Longevity Science Into Formulation Strategy

Innovation comes naturally for the human body through thousands of years of evolution. Nature is the world’s great innovator. People age for over a 100 years and still remain functional. Despite the environmental ravages of the modern world, such as ever-increasing pathogens, toxins, and immune stimulating antigens, the human body and its protective epithleial tissues, incuding the skin, remain highly functional for decades. Learning from nature, NeoGenesis creates, manufactures, and sells the most innovative skin care products on the market.

NeoGenesis is a dynamic, innovative, and customer-focused formulator, manufacturer, and distributor of high-quality, efficacious skin and personal care products.With decades of scientific research by our cofounder, Prof. Dr. Greg Maguire, Ph.D. and industry experience and knowledge, we offer a wide variety of topical products, consultative support and educational resources to help each of our customers navigate the complex world of skin care for all of the various skin conditions that can afflict us; from skin longevity care, to eczema, to radiation dermatitis, NeoGenesis’ products can mitigate and prevent many of the symptoms and underlying mechanisms in these skin conditions.

NeoGenesis’ Skin Care Product Portfolio features a comprehensive range of innovative, functional ingredients for skin care and personal care, including our Stem Cell Released Molecules technology (S2RM) comprised of exosomes, ectosomes, and soluble fractions from skin-identical stem cells, NMFs, Triple Lipid Technology, emollients, antioxidants, botanical extracts, prebiotics, probiotics, and postbiotics, and natural preservatives – all designed to enhance product performance and support sustainable formulation trends.

At NeoGenesis, we biohack the natural way. The way mother nature intended and taught us. We use a biomemtic approach where the molecules that are native to the skin when the skin is young and healthy, are retuned to the skin in those many skin conditions that have an underlying deficit in these molecules.

Whether it’s molecules derived from our diet or the molecules made in the body, NeoGenesis uses a combination of these molecules to feed the skin from the outside-in, using all of the molecules needed to mainatain an opitmal longevity startegy for skin care. As an example, the skin has a number of stem cell types that provide a rich variety of molecules to maintain skin longevity. In our research paper on proteomics of these molecules, we explained the many proteins in the S2RM that promote cellular and tissue longevity. The S2RM is the full collection of molecules released by two major stem cell types in the skin that underly many skin functions. Again, these molecules from the stem cells in our skin can be compromised simply during the aging process. Using NeoGenesis products that contain the S2RM technology, such as Recovery and Skin Serum, returns to the skin the molecules that were present when the skin was young and healthy, thus leading to the skin’s improved longevity.

And when combining our S2RM technology-containing products with, for example, our Vibrant C Serum product to provide ascorbic acid to the skin, a synergistic result is realized. Ascorbic acid is essential to human skin health and is not produced by the body, but must be obtained through diet. Unfortunately, most people have a deficiency of ascorbic acid in their skin and topical application in a liposomal form can provide fresh, non-oxidized ascorbic acid deep into the skin to support collagen production and protection, as well as numerous other benefits that increase skin longevity.